Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312908 | 0.90 | KMT2A (0.45) | KMT2AGAAALDH1A1POLBMEN1 | |
| SCHEMBL8314804 | 0.87 | SIGMAR1 (0.43) | KMT2AALDH1A1POLBSMN1; SMN2SIGMAR1 | |
| SCHEMBL9220150 | 0.87 | KMT2A (0.44) | KMT2AGAAOPRK1OPRM1ALDH1A1 | |
| SCHEMBL8314523 | 0.85 | KMT2A (0.38) | KMT2AGAAALDH1A1POLBMEN1 | |
| SCHEMBL8875468 | 0.83 | KMT2A (0.40) | KMT2AGAAALDH1A1POLBMEN1 | |
| SCHEMBL8314253 | 0.83 | KMT2A (0.36) | KMT2AGAAALDH1A1POLBMEN1 | |
| SCHEMBL8313835 | 0.82 | KMT2A (0.42) | KMT2AOPRK1OPRM1ALDH1A1MEN1 | |
| SCHEMBL9539327 | 0.80 | OPRK1 (0.42) | KMT2AOPRK1OPRM1MEN1SMN1; SMN2 | |
| SCHEMBL8315795 | 0.79 | CCR1 (0.37) | KMT2AGAAALDH1A1POLBMEN1 | |
| SCHEMBL8316895 | 0.77 | HSD11B1 (0.33) | KMT2AGAAALDH1A1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |