Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312908 | 0.90 | KMT2A (0.45) | KMT2AGAAALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL8314523 | 0.89 | KMT2A (0.38) | KMT2AGAACCR1ALDH1A1MEN1 | |
| SCHEMBL9220150 | 0.86 | KMT2A (0.44) | KMT2AGAAALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL8313857 | 0.83 | KMT2A (0.35) | KMT2AGAACCR1ALDH1A1MEN1 | |
| SCHEMBL8317256 | 0.83 | ALDH1A1 (0.39) | KMT2AGAAALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL8876096 | 0.83 | KMT2A (0.41) | KMT2AGAAALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL8315795 | 0.82 | CCR1 (0.37) | KMT2AGAACCR1ALDH1A1MEN1 | |
| SCHEMBL8318118 | 0.81 | ALDH1A1 (0.45) | KMT2AALDH1A1MEN1SMN1; SMN2MAPT | |
| SCHEMBL8314804 | 0.79 | SIGMAR1 (0.43) | KMT2AALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL8316864 | 0.76 | ALDH1A1 (0.38) | KMT2AGAAALDH1A1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |