Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089588 | 0.78 | NR3C1 (0.48) | IMPDH2 | |
| SCHEMBL6089244 | 0.75 | NR3C1 (0.39) | IMPDH2CLK1CDK5CDK5R1MEN1 | |
| SCHEMBL6245404 | 0.70 | TAAR1 (0.33) | IMPDH2MEN1RAB9AKMT2A | |
| SCHEMBL15368479 | 0.70 | ESR1 (0.49) | MEN1KMT2AESR1 | |
| SCHEMBL27174846 | 0.68 | IMPDH2 (0.46) | IMPDH2CLK1CDK5CDK5R1MEN1 | |
| SCHEMBL6090728 | 0.63 | IMPDH2 (0.39) | IMPDH2CLK1CDK5CDK5R1MEN1 | |
| SCHEMBL7089054 | 0.62 | REN (0.50) | IMPDH2CLK1CDK5CDK5R1PARP1 | |
| SCHEMBL6092231 | 0.61 | KIF11 (0.34) | IMPDH2MEN1KMT2AESR1PARP1 | |
| SCHEMBL8320226 | 0.60 | IMPDH2 (0.36) | IMPDH2CLK1CDK5CDK5R1MEN1 | |
| SCHEMBL7029009 | 0.60 | GPR84 (0.49) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |