Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324682 | 0.84 | TP53 (0.40) | TAAR1PPARGPPARANPC1SLC6A2 | |
| SCHEMBL8323592 | 0.83 | NOS3 (0.40) | NFE2L2PPARGPPARAMAOBSLC6A2 | |
| SCHEMBL8326976 | 0.82 | MAOB (0.45) | TAAR1CYP2D6NPC1MAOBSLC6A2 | |
| SCHEMBL8327755 | 0.82 | PNMT (0.41) | TAAR1NPC1CHRM5RAB9AMAOB | |
| SCHEMBL8322396 | 0.82 | HTR2A (0.46) | NFE2L2MEN1KMT2APPARGPPARA | |
| SCHEMBL8324959 | 0.81 | SIGMAR1 (0.39) | TAAR1SLC6A2MAOASLC6A4SLC6A3 | |
| SCHEMBL8330718 | 0.80 | NFE2L2 (0.49) | NFE2L2TAAR1PPARGPPARACYP1A2 | |
| SCHEMBL8323270 | 0.79 | KDM4E (0.36) | MEN1KMT2APPARGPPARACYP3A4 | |
| SCHEMBL8322850 | 0.77 | NFE2L2 (0.45) | NFE2L2TAAR1PPARGPPARACYP1A2 | |
| SCHEMBL8325718 | 0.75 | CYP2C19 (0.40) | TAAR1PPARGPPARAMAOBSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |