Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322987 | 0.85 | NPC1 (0.52) | HTR2AHTR2BHTR2CPPARGPPARA | |
| SCHEMBL8324481 | 0.82 | NFE2L2 (0.45) | PPARGPPARASIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL8320387 | 0.82 | HTR2A (0.53) | HTR2AHTR2BHTR2CPPARGPPARA | |
| SCHEMBL8324682 | 0.80 | TP53 (0.40) | HTR2APPARGPPARASIGMAR1TP53 | |
| SCHEMBL8327755 | 0.79 | PNMT (0.41) | SIGMAR1TSHRGRIN1GRIN2BNPC1 | |
| SCHEMBL8326976 | 0.79 | MAOB (0.45) | HTR2ASIGMAR1CYP2D6MAPTADRA2C | |
| SCHEMBL8326920 | 0.78 | HTR2A (0.46) | HTR2AHTR2BHTR2CPPARGPPARA | |
| SCHEMBL8324959 | 0.78 | SIGMAR1 (0.39) | HTR2ASIGMAR1ADRA2CSLC6A4ADRA1A | |
| SCHEMBL24305725 | 0.74 | NFE2L2 (0.41) | HTR2AHTR2BHTR2CPPARGPPARA | |
| SCHEMBL8323592 | 0.74 | NOS3 (0.40) | HTR2APPARGPPARASIGMAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |