Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326920 | 0.85 | HTR2A (0.46) | NPC1RAB9APPARGPPARASIGMAR1 | |
| SCHEMBL8324972 | 0.83 | TAAR1 (0.44) | NOS3NOS1NOS2PPARGPPARA | |
| SCHEMBL8325444 | 0.81 | TAAR1 (0.46) | PPARGPPARATAAR1SIGMAR1SLC18A2 | |
| SCHEMBL8326251 | 0.80 | NPC1 (0.59) | NPC1RAB9ANOS3NOS1NOS2 | |
| SCHEMBL8323399 | 0.78 | LTA4H (0.50) | PPARGPPARAFPR2TAAR1SIGMAR1 | |
| SCHEMBL8322987 | 0.77 | NPC1 (0.52) | NPC1RAB9ANOS3NOS1NOS2 | |
| SCHEMBL8322850 | 0.73 | NFE2L2 (0.45) | NPC1RAB9APPARGPPARATAAR1 | |
| SCHEMBL8322029 | 0.73 | CYP3A4 (0.40) | NPC1RAB9ANOS2PPARGPPARA | |
| SCHEMBL8327429 | 0.72 | TAAR1 (0.42) | NPC1TAAR1SIGMAR1SLC18A2TP53 | |
| SCHEMBL8325015 | 0.71 | MAOA (0.45) | TAAR1SIGMAR1SLC18A2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |