Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322396 | 0.85 | HTR2A (0.46) | NPC1RAB9APPARGPPARAMAPT | |
| SCHEMBL8323592 | 0.83 | NOS3 (0.40) | NOS3NOS1NOS2PPARGPPARA | |
| SCHEMBL8325718 | 0.81 | CYP2C19 (0.40) | PPARGPPARAMAPTLMNASLC6A4 | |
| SCHEMBL8326251 | 0.80 | NPC1 (0.59) | NPC1RAB9ANOS3NOS1NOS2 | |
| SCHEMBL8324438 | 0.78 | G6PC1 (0.48) | PPARGPPARAMAPTOPRM1SLC6A4 | |
| SCHEMBL8326774 | 0.77 | NPC1 (0.52) | NPC1RAB9ANOS3NOS1NOS2 | |
| SCHEMBL8324481 | 0.73 | NFE2L2 (0.45) | NPC1RAB9APPARGPPARAMAPK1 | |
| SCHEMBL8323270 | 0.73 | KDM4E (0.36) | NOS2PPARGPPARAMAPTSLC6A4 | |
| SCHEMBL8324682 | 0.72 | TP53 (0.40) | NPC1PPARGPPARASLC6A4ALDH1A1 | |
| SCHEMBL8326976 | 0.71 | MAOB (0.45) | NPC1MAPTSLC6A4SIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |