Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325444 | 0.83 | TAAR1 (0.46) | PPARGPPARASIGMAR1TAAR1SLC18A2 | |
| SCHEMBL8324972 | 0.81 | TAAR1 (0.44) | PPARGPPARASIGMAR1ALDH1A1TAAR1 | |
| SCHEMBL8323072 | 0.80 | TRPA1 (0.50) | LTA4HTRPA1PPARGPPARASIGMAR1 | |
| SCHEMBL8326774 | 0.78 | NPC1 (0.52) | PPARGPPARASIGMAR1TAAR1SLC18A2 | |
| SCHEMBL8324438 | 0.76 | G6PC1 (0.48) | LTA4HTRPA1PPARGPPARASIGMAR1 | |
| SCHEMBL25660764 | 0.74 | LDHA (0.50) | LTA4HALDH1A1 | |
| SCHEMBL8327429 | 0.73 | TAAR1 (0.42) | SIGMAR1ALDH1A1TAAR1SLC18A2 | |
| SCHEMBL8325015 | 0.72 | MAOA (0.45) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| SCHEMBL8322850 | 0.72 | NFE2L2 (0.45) | PPARGPPARASIGMAR1TAAR1SLC18A2 | |
| SCHEMBL8324981 | 0.72 | GRIN1 (0.43) | SIGMAR1ALDH1A1TAAR1SLC18A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |