Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320621 | 0.82 | POLB (0.60) | MEN1KMT2ALMNAUSP2SMN1; SMN2 | |
| SCHEMBL8327337 | 0.81 | TSHR (0.58) | MEN1KMT2AMAPTLMNAUSP2 | |
| SCHEMBL13218242 | 0.80 | MEN1 (0.37) | MEN1KMT2AMAPTLMNAUSP2 | |
| SCHEMBL13201342 | 0.80 | MMP2 (0.52) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL8319376 | 0.80 | EPHX2 (0.48) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL8324756 | 0.79 | MMP2 (0.46) | ALDH1A1MMP2MMP9MMP12GAA | |
| SCHEMBL13201315 | 0.78 | MMP2 (0.46) | TSHRMMP2MMP9MMP12 | |
| SCHEMBL8328602 | 0.78 | MEN1 (0.56) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL8320651 | 0.78 | MMP9 (0.62) | MMP2MMP9MMP12 | |
| SCHEMBL8319573 | 0.77 | MMP2 (0.44) | KMT2ALMNAALDH1A1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |