Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | GPR27 | Q9NS67 | 7/20 | 0.50 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324687 | 0.91 | MEN1 (0.57) | MEN1KMT2AGPR27AVPR2GAA | |
| SCHEMBL13201330 | 0.81 | MMP8 (0.52) | MEN1KMT2A | |
| SCHEMBL8320621 | 0.80 | POLB (0.60) | MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL13218243 | 0.80 | ALDH1A1 (0.36) | MEN1KMT2AGPR27AVPR2ALDH1A1 | |
| SCHEMBL8326140 | 0.79 | PSEN1 (0.52) | MEN1KMT2A | |
| SCHEMBL8327337 | 0.78 | TSHR (0.58) | MEN1KMT2AGAAALDH1A1KDM4E | |
| SCHEMBL8328109 | 0.78 | MEN1 (0.59) | MEN1KMT2AGAAALDH1A1KDM4E | |
| SCHEMBL13201315 | 0.77 | MMP2 (0.46) | — | |
| SCHEMBL13201342 | 0.76 | MMP2 (0.52) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL8319573 | 0.76 | MMP2 (0.44) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |