Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 13/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327888 | 0.83 | MAPT (0.38) | ADORA1PDE10AMAPTRAB9A | |
| SCHEMBL8329797 | 0.83 | MAPK8 (0.44) | MAPK8GRM5PKMSMN1; SMN2 | |
| SCHEMBL8328465 | 0.80 | PTGS2 (0.40) | PDE10AMAPT | |
| SCHEMBL8329796 | 0.78 | THRB (0.46) | MAPK8TP53MAPTSMN1; SMN2 | |
| SCHEMBL8325619 | 0.77 | THRB (0.31) | — | |
| SCHEMBL8328091 | 0.77 | SYK (0.38) | MAPK8NPC1LMNATP53MAPT | |
| Hydrochloric Acid SCHEMBL8325645 | 0.77 | THRB (0.45) | MAPK8TP53MAPTPKMSMN1; SMN2 | |
| SCHEMBL8327617 | 0.72 | GRM5 (0.45) | MAPK8GRM5TP53 | |
| Hydrochloric Acid SCHEMBL8326798 | 0.72 | GRM5 (0.44) | MAPK8GRM5TP53 | |
| SCHEMBL8329054 | 0.70 | MAPT (0.42) | MAPK8ADORA1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |