SCHEMBL8329943

SCHEMBL8329943

CCc1nccc(NC(=O)Cc2ccc(Oc3ccc(Cl)cc3)cc2)c1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOD2 Q9HC29 1/20 0.48
KMT2A Q03164 4/20 0.46
L3MBTL1 Q9Y468 3/20 0.46
MEN1 O00255 3/20 0.46
MAPT P10636 1/20 0.46
ALDH1A1 P00352 3/20 0.46
RAB9A P51151 2/20 0.45
NPC1 O15118 1/20 0.45
KDM5A P29375 1/20 0.45
KDM4C Q9H3R0 1/20 0.45
KDM5B Q9UGL1 1/20 0.45
LTA4H P09960 1/20 0.45
EPHX2 P34913 1/20 0.45
CSNK1D P48730 2/20 0.44
FFAR2 O15552 1/20 0.44
MAPK10 P53779 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CNR2 P34972 1/20 0.41
RORC P51449 1/20 0.41
P2RX3 P56373 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27550688 0.89 NOD2 (0.49) NOD2KMT2AL3MBTL1MEN1ALDH1A1
SCHEMBL8413441 0.88 NOD2 (0.44) NOD2KMT2AL3MBTL1MEN1MAPT
SCHEMBL8330868 0.88 EPHX2 (0.46) NOD2L3MBTL1MAPTLTA4HEPHX2
SCHEMBL8412094 0.84 NOD2 (0.44) NOD2KMT2AL3MBTL1MEN1ALDH1A1
SCHEMBL8331056 0.82 NLRP3 (0.45) NOD2KMT2AMEN1MAPTALDH1A1
SCHEMBL8410599 0.81 LMNA (0.48) NOD2RAB9A
SCHEMBL9231797 0.81 MAPT (0.45) NOD2L3MBTL1MAPTRORCP2RX3
SCHEMBL8412024 0.81 L3MBTL1 (0.47) NOD2KMT2AL3MBTL1MEN1MAPT
SCHEMBL8987834 0.77 KMT2A (0.51) KMT2AL3MBTL1MEN1MAPTALDH1A1
SCHEMBL7621606 0.76 MAPK1 (0.45) KMT2AL3MBTL1MEN1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0556381-B1 N-(4-PYRIDYL OR 4-QUINOLINYL) ARYLACETAMIDE PESTICIDES DOW AGROSCIENCES LLC (US) 1999-04-28 EP claimed
US-5597836-A NEMATOCIDES, INSECTICIDES, MITICIDES AND PLANT PATHOGENS DOWELANCO (US) 1997-01-28 US claimed
EP-0556381-A4 DOWELANCO (US) 1995-06-21 EP claimed
EP-0556381-A1 N-(4-PYRIDYL OR 4-QUINOLINYL) ARYLACETAMIDE PESTICIDES DOWELANCO (US) 1993-08-25 EP claimed
WO-1993004580-A1 N-(4-PYRIDYL OR 4-QUINOLINYL) ARYLACETAMIDE PESTICIDES DOWELANCO (US) 1993-03-18 WO claimed
EP-0822930-B1 PYRIDINE DERIVATIVE AND PESTICIDE KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-07-28 EP disclosed
CN-1223640-A Substituted N- (4-pyridyl) -thioamides with insecticidal activity BAYER AG (DE) 1999-07-21 CN disclosed
EP-0556381-B1 N-(4-PYRIDYL OR 4-QUINOLINYL) ARYLACETAMIDE PESTICIDES DOW AGROSCIENCES LLC (US) 1999-04-28 EP disclosed
US-5763463-A Pyridine compounds which are useful as pesticides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1998-06-09 US disclosed
EP-0822930-A1 PYRIDINE DERIVATIVE AND PESTICIDE KumaiI Chemical Industry Co., Ltd. (JP) 1998-02-11 EP disclosed
US-5597836-A NEMATOCIDES, INSECTICIDES, MITICIDES AND PLANT PATHOGENS DOWELANCO (US) 1997-01-28 US disclosed
WO-1996033975-A1 PYRIDINE DERIVATIVE AND PESTICIDE KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1996-10-31 WO disclosed
EP-0556381-A4 DOWELANCO (US) 1995-06-21 EP disclosed
US-5399564-A N-(4-pyridyl or 4-quinolinyl) arylacetamide and 4-(aralkoxy or aralkylamino) pyridine pesticides DOWELANCO (US) 1995-03-21 US disclosed
EP-0556381-A1 N-(4-PYRIDYL OR 4-QUINOLINYL) ARYLACETAMIDE PESTICIDES DOWELANCO (US) 1993-08-25 EP disclosed
WO-1993004580-A1 N-(4-PYRIDYL OR 4-QUINOLINYL) ARYLACETAMIDE PESTICIDES DOWELANCO (US) 1993-03-18 WO disclosed