Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8333655 | 0.84 | — | — | |
| SCHEMBL8334835 | 0.82 | GAA (0.31) | KMT2AGAAHIF1AALDH1A1 | |
| SCHEMBL8335857 | 0.82 | GAA (0.31) | KMT2AGAAHIF1AALDH1A1 | |
| SCHEMBL8336900 | 0.80 | KMT2A (0.37) | TSHRMEN1KMT2AGAAHTT | |
| SCHEMBL8334767 | 0.80 | ALDH1A1 (0.33) | KMT2AGAAHIF1AALDH1A1MAPT | |
| SCHEMBL8336357 | 0.79 | HIF1A (0.34) | HIF1AALDH1A1MAPTALOX12 | |
| SCHEMBL8333752 | 0.79 | HIF1A (0.34) | HIF1AALDH1A1MAPTALOX12 | |
| SCHEMBL8336673 | 0.78 | CNR2 (0.35) | MEN1KMT2AGAAPOLB | |
| SCHEMBL8333474 | 0.78 | NPSR1 (0.33) | GAAHIF1AALDH1A1KDM4EMAPT | |
| SCHEMBL8389248 | 0.77 | TAS1R3 (0.32) | HIF1AALDH1A1MAPTNPSR1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8245556-A | — | — | None | — | — | JP | disclosed |
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |
| JP-H08245556-A | SUBSTITUTED BENZENESULFONYLUREA AND-THIOUREA, THEIR PREPARATION AND THEIR USE FOR PHARMACEUTICAL PREPARATION BASED ON THE COMPOUNDS, AND MBDICAMENT CONTAINING THEM | HOECHST AG | 1996-09-24 | — | — | JP | disclosed |