Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336669 | 0.83 | SIGMAR1 (0.32) | — | |
| SCHEMBL8341066 | 0.80 | — | — | |
| SCHEMBL8334475 | 0.79 | CNR1 (0.33) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL8389972 | 0.77 | ALDH1A1 (0.34) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL8336013 | 0.73 | P2RX7 (0.31) | — | |
| SCHEMBL8335851 | 0.68 | CNR2 (0.38) | ALDH1A1MEN1HTTKMT2ANPSR1 | |
| SCHEMBL8341128 | 0.67 | CNR2 (0.36) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8334765 | 0.67 | HPGD (0.37) | POLBALDH1A1MAPTMEN1HTT | |
| SCHEMBL8339611 | 0.67 | — | — | |
| SCHEMBL8334832 | 0.67 | CNR2 (0.37) | RAB9APOLBALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |