Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340005 | 0.81 | DRD3 (0.31) | CNR2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8335797 | 0.79 | OPRK1 (0.41) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL8339176 | 0.79 | OPRM1 (0.39) | CYP2D6LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19049385 | 0.67 | PDE2A (0.44) | CYP2D6GSK3BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8339200 | 0.67 | DRD3 (0.36) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL27873292 | 0.67 | CNR2 (0.48) | CNR2CYP2D6GSK3B | |
| SCHEMBL19002794 | 0.67 | DRD3 (0.47) | LMNA | |
| SCHEMBL8339477 | 0.65 | GPR88 (0.40) | CNR2CYP1A2CYP3A4CYP2C9PKM | |
| SCHEMBL9906056 | 0.64 | LMNA (0.46) | CNR2CYP2D6GSK3BLMNA | |
| SCHEMBL24394579 | 0.63 | CYP2D6 (0.46) | CNR2CYP2D6GSK3BSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |