Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337813 | 0.89 | TDP1 (0.39) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8336514 | 0.87 | PKM (0.37) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8338276 | 0.86 | TAS1R3 (0.37) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8340431 | 0.84 | MMP9 (0.39) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8337089 | 0.83 | MMP9 (0.43) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8336849 | 0.82 | MMP9 (0.44) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8339477 | 0.82 | GPR88 (0.40) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8334276 | 0.80 | ALOX5 (0.34) | RAB9AMEN1KMT2AGPR88CNR2 | |
| SCHEMBL8334203 | 0.78 | GAA (0.34) | RAB9AMEN1KMT2AGPR88CNR2 | |
| SCHEMBL8338089 | 0.78 | TDP1 (0.37) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |