Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352104 | 0.86 | CFD (0.59) | MAPK8MAPK10SMN1; SMN2HTT | |
| SCHEMBL8349452 | 0.84 | JAK2 (0.61) | ALDH1A1HPGDTSHRMAPK1RECQL | |
| SCHEMBL8351021 | 0.82 | HPGD (0.56) | ALDH1A1HPGDMAPK1MAPK8MAPK10 | |
| SCHEMBL8350912 | 0.80 | CSNK1D (0.53) | MAPK8MAPK10MAPTKMT2AMEN1 | |
| SCHEMBL8352106 | 0.80 | SMN1; SMN2 (0.52) | MAPK8MAPK10MAPTTP53SMN1; SMN2 | |
| SCHEMBL29817974 | 0.80 | ALDH1A1 (0.60) | ALDH1A1HPGDTSHRMAPK1RECQL | |
| SCHEMBL8349000 | 0.79 | MAPK10 (0.48) | ALDH1A1MAPK8MAPK10 | |
| SCHEMBL577333 | 0.77 | ALDH1A1 (0.69) | ALDH1A1HPGDTSHRMAPK1RECQL | |
| SCHEMBL8352200 | 0.76 | MEN1 (0.60) | MAPK8MAPK10POLBKMT2AMEN1 | |
| SCHEMBL14254327 | 0.76 | MAPK8 (0.59) | MAPK1MAPK8MAPK10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |