Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | ACACA | Q13085 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.48 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349003 | 0.84 | ATM (0.63) | MEN1KMT2APIP5K1CPIK3CAMAPK10 | |
| SCHEMBL8354483 | 0.84 | CAMKK2 (0.56) | MEN1KMT2AMAPK10MAPK8HDAC6 | |
| SCHEMBL1927570 | 0.83 | MEN1 (0.83) | MEN1KMT2AHDAC6POLBROCK2 | |
| SCHEMBL8352104 | 0.81 | CFD (0.59) | MAPK10MAPK8HDAC6ROCK2ROCK1 | |
| SCHEMBL29836789 | 0.79 | MEN1 (0.53) | MEN1KMT2AHDAC6POLBACACB | |
| SCHEMBL29818223 | 0.78 | MEN1 (0.52) | MEN1KMT2AHDAC6POLBACACB | |
| SCHEMBL31331640 | 0.77 | MEN1 (0.71) | MEN1KMT2AMAPK14HDAC6POLB | |
| SCHEMBL8351088 | 0.76 | ALDH1A1 (0.62) | MEN1KMT2AMAPK10MAPK8POLB | |
| SCHEMBL10722330 | 0.76 | MEN1 (0.81) | MEN1KMT2AHDAC6POLB | |
| SCHEMBL29818071 | 0.76 | DGAT1 (0.51) | MEN1KMT2AMAPK14HDAC6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |