Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | ROS1 | P08922 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352104 | 0.87 | CFD (0.59) | MAPK8MAPK10EPHX2NR1H4ROCK1 | |
| SCHEMBL8352106 | 0.85 | SMN1; SMN2 (0.52) | MAPK8MAPK10MAPTROCK1JAK2 | |
| SCHEMBL8349712 | 0.85 | ABL1 (0.53) | CSNK1DMAPK8MAPK10CYP2C9CHRNB2 | |
| SCHEMBL1928101 | 0.83 | CHRNB2 (0.64) | CSNK1DCYP2C9CHRNB2CHRNA4MEN1 | |
| SCHEMBL8349000 | 0.82 | MAPK10 (0.48) | MAPK8MAPK10EPHX2NR1H4ROCK1 | |
| SCHEMBL8351088 | 0.80 | ALDH1A1 (0.62) | MAPK8MAPK10MEN1MAPTKMT2A | |
| SCHEMBL8351021 | 0.80 | HPGD (0.56) | MAPK8MAPK10MEN1MAPTKMT2A | |
| SCHEMBL6798961 | 0.78 | CYP2C9 (0.54) | CSNK1DCYP2C9CHRNB2CHRNA4MEN1 | |
| SCHEMBL5213910 | 0.78 | CA2 (0.54) | CSNK1DCYP2C9CHRNB2CHRNA4MEN1 | |
| SCHEMBL8351466 | 0.77 | ROCK2 (0.64) | MAPK8MAPK10CYP2C9EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |