Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 5/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | GRK2 | P25098 | 5/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | FES | P07332 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349425 | 0.85 | ABL1 (0.53) | MAPK10MAPK8PRKCAJAK2PRKCG | |
| SCHEMBL8352104 | 0.83 | CFD (0.59) | MAPK10MAPK8AURKAGRK2ROCK2 | |
| SCHEMBL8350912 | 0.82 | CSNK1D (0.53) | MAPK10MAPK8ROCK1JAK2MAP4K4 | |
| SCHEMBL8352106 | 0.81 | SMN1; SMN2 (0.52) | MAPK10MAPK8GRK2ROCK2PRKCA | |
| SCHEMBL8351088 | 0.79 | ALDH1A1 (0.62) | MAPK10MAPK8ALDH1A1 | |
| SCHEMBL8351021 | 0.78 | HPGD (0.56) | MAPK10MAPK8ALDH1A1LMNA | |
| SCHEMBL1518861 | 0.75 | MAPK1 (0.54) | MAPK10MAPK8ROCK2PIP5K1CPIK3CA | |
| SCHEMBL8352200 | 0.74 | MEN1 (0.60) | MAPK10MAPK8ROCK2PIP5K1CPIK3CA | |
| SCHEMBL14254327 | 0.74 | MAPK8 (0.59) | MAPK10MAPK8PIP5K1CPIK3CAROCK1 | |
| SCHEMBL8351466 | 0.73 | ROCK2 (0.64) | MAPK10MAPK8ROCK2ROCK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |