Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | FES | P07332 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351466 | 0.89 | ROCK2 (0.64) | EPHX2NR1H4MAPK8MAPK10MAP4K4 | |
| SCHEMBL8350912 | 0.87 | CSNK1D (0.53) | CFDEPHX2NR1H4MAPK8MAPK10 | |
| SCHEMBL8351088 | 0.86 | ALDH1A1 (0.62) | MAPK8MAPK10HTTSMN1; SMN2 | |
| SCHEMBL8351021 | 0.85 | HPGD (0.56) | MAPK8MAPK10LMNAHTTSMN1; SMN2 | |
| SCHEMBL8352106 | 0.84 | SMN1; SMN2 (0.52) | MAPK8MAPK10JAK2ROCK1ROCK2 | |
| SCHEMBL8349000 | 0.83 | MAPK10 (0.48) | EPHX2NR1H4MAPK8MAPK10JAK2 | |
| SCHEMBL8352521 | 0.82 | ABL1 (0.58) | CFDEPHX2NR1H4MAPK8MAPK10 | |
| SCHEMBL8350880 | 0.81 | MAPK8 (0.54) | MAPK8MAPK10JAK2MAP4K4PRKCG | |
| SCHEMBL8352200 | 0.81 | MEN1 (0.60) | MAPK8MAPK10ROCK1ROCK2HDAC6 | |
| SCHEMBL14254327 | 0.80 | MAPK8 (0.59) | MAPK8MAPK10ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |