Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | PKLR | P30613 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28774873 | 0.98 | LMNA (0.56) | LMNAPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL84337 | 0.87 | POLB (0.66) | LMNAPKMALDH1A1SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL27712068 | 0.85 | POLB (0.64) | LMNAPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL12799099 | 0.85 | ALDH1A1 (0.59) | LMNAPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL14549419 | 0.84 | LMNA (0.65) | LMNAPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL10303833 | 0.83 | PKM (0.66) | LMNAPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL609522 | 0.83 | LMNA (0.57) | LMNAPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4055826 | 0.81 | SMN1; SMN2 (0.57) | LMNAPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL14620302 | 0.81 | ALDH1A1 (0.49) | LMNAPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL610238 | 0.81 | LMNA (0.54) | LMNAPKMALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 248 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101454289-B | Substituted tetrahydroisoquinoline compounds, their preparation and use in medicine | ESTEVE LABOR DR | 2012-07-04 | — | — | CN | claimed |
| EP-2007729-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2012-06-27 | — | — | EP | claimed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | claimed |
| EP-2079701-A1 | SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-07-22 | — | — | EP | claimed |
| CN-101454289-A | Substituted tetrahydroisoquinoline compounds, their preparation and use in medicine | ESTEVE LABOR DR (ES) | 2009-06-10 | — | — | CN | claimed |
| EP-2007729-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-12-31 | — | — | EP | claimed |
| WO-2008043544-A1 | SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-04-17 | — | — | WO | claimed |
| US-7312218-B2 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL MYERS SQUIBB CO. (US) | 2007-12-25 | — | — | US | claimed |
| WO-2007107373-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (DE) | 2007-09-27 | — | — | WO | claimed |
| US-20070099922-A1 | SULFONYLAMINOVALEROLACTAMS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | HAN WEI | 2007-05-03 | — | — | US | claimed |
| US-6919333-B2 | Bis-transition-metal-chelate probes | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2005-07-19 | — | — | US | claimed |
| US-20050096309-A1 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-05-05 | — | — | US | claimed |
| WO-2005029075-A1 | BIS-TRANSITION-METAL-CHELATE PROBES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2005-03-31 | — | — | WO | claimed |
| EP-1506402-A2 | BIS-TRANSITION-METAL-CHELATE-PROBES | Rutgers, The State University of New Jersey (US) | 2005-02-16 | — | — | EP | claimed |
| US-20040096887-A1 | Bis-transition-metal-chelate probes | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-05-20 | — | — | US | claimed |
| US-20040019104-A1 | Reagents and procedures for high-specificity labeling | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-01-29 | — | — | US | claimed |
| WO-2003107010-A1 | REAGENTS AND PROCEDURES FOR HIGH-SPECIFICITY LABELING | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2003-12-24 | — | — | WO | claimed |
| WO-2003091689-A2 | BIS-TRANSITION-METAL-CHELATE-PROBES | RUTGERS, THE STATE OF UNIVERSITY OF NEW JERSEY (US) | 2003-11-06 | — | — | WO | claimed |
| WO-2021063999-A1 | ISOINDOLINE DERIVATIVES | BASF COLORS & EFFECTS GMBH (DE) | 2021-04-08 | — | — | WO | disclosed |
| EP-0329491-A2 | Photographic elements incorporating antihalation and/or acutance dyes | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1989-08-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099922-A1 | SULFONYLAMINOVALEROLACTAMS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | TFPI, F12, F5 | LMNA 558/4885PKM 2117/4885ALDH1A1 2753/4885 |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | HTR6, HTR5A, HTR7 | LMNA 2234/4885PKM 1602/4885ALDH1A1 1731/4885 |
| US-20040096887-A1 | Bis-transition-metal-chelate probes | SCO2, CDY1; CDY1B, PYM1 | LMNA 1283/4885PKM 2832/4885ALDH1A1 1285/4885 |
| US-20040019104-A1 | Reagents and procedures for high-specificity labeling | AS3MT, SRMS, HNRNPH3 | LMNA 1454/4885PKM 2309/4885ALDH1A1 3876/4885 |
| US-20050096309-A1 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | TFPI, F12, F5 | LMNA 558/4885PKM 2117/4885ALDH1A1 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.