Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 2/20 | 0.32 |
| ▸ | USP1 | O94782 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407844 | 0.83 | POLB (0.44) | POLBUSP1JAK2JAK1JAK3 | |
| SCHEMBL8405232 | 0.71 | ADORA2A (0.46) | POLBCYP1A2 | |
| SCHEMBL8404996 | 0.67 | PDE4A (0.51) | — | |
| SCHEMBL22822724 | 0.63 | USP1 (0.37) | POLBUSP1JAK2JAK1JAK3 | |
| SCHEMBL897035 | 0.63 | ADORA2B (0.55) | CYP1A2 | |
| SCHEMBL8407697 | 0.63 | GSK3B (0.45) | — | |
| SCHEMBL8407994 | 0.62 | ADORA3 (0.47) | — | |
| SCHEMBL8407792 | 0.61 | ATM (0.48) | POLBCYP1A2 | |
| SCHEMBL19200146 | 0.59 | POLB (0.44) | POLBUSP1 | |
| SCHEMBL22419395 | 0.58 | USP1 (0.41) | POLBUSP1JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673938-B1 | Purine derivatives and pharmaceutically acceptable salts thereof | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 1999-07-07 | — | — | EP | disclosed |
| US-5658918-A | INHIBITING NASAL MUCOUS SECRETION | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| EP-0673938-A2 | Novel purine derivatives and pharmaceutically acceptable salts thereof | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1995-09-27 | — | — | EP | disclosed |