Morphine 3-Glucuronide

SCHEMBL8409700

[2H]O[C@]1([2H])[C@@H](O)[C@H](O)[C@@H](C(=O)O)O[C@@]1([2H])Oc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	OPRM1	P35372	6/20	0.62

▸	OPRD1	P41143	6/20	0.62

▸	MRGPRX2	Q96LB1	5/20	0.62

▸	OPRK1	P41145	4/20	0.62

▸	ADRB1	P08588	1/20	0.62

▸	PDE4D	Q08499	1/20	0.62

▸	PDE3A	Q14432	1/20	0.62

▸	SLC22A1	O15245	1/20	0.55

▸	ADRA2A	P08913	1/20	0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Morphine 3-Glucuronide SCHEMBL8412630	1.00	OPRM1 (0.62)	OPRM1OPRD1MRGPRX2OPRK1ADRB1
SCHEMBL8409388	0.86	MRGPRX2 (0.77)	OPRM1OPRD1MRGPRX2OPRK1ADRB1
Morphine 3-Glucuronide SCHEMBL614298	0.86	MRGPRX2 (0.74)	OPRM1OPRD1MRGPRX2OPRK1ADRB1
Morphine 3-Glucuronide SCHEMBL3843209	0.86	MRGPRX2 (0.74)	OPRM1OPRD1MRGPRX2OPRK1ADRB1
Morphine Glucuronide SCHEMBL8410898	0.83	OPRM1 (0.76)	OPRM1OPRD1MRGPRX2OPRK1
Morphine Glucuronide SCHEMBL8411986	0.83	OPRM1 (0.76)	OPRM1OPRD1MRGPRX2OPRK1
SCHEMBL8412616	0.79	OPRD1 (0.75)	OPRM1OPRD1MRGPRX2OPRK1ADRB1
Codeine SCHEMBL3476555	0.79	OPRD1 (0.91)	OPRM1OPRD1MRGPRX2OPRK1ADRB1
Morphine SCHEMBL9219855	0.79	OPRM1 (0.75)	OPRM1OPRD1MRGPRX2OPRK1SLC22A1
SCHEMBL2171816	0.79	MRGPRX2 (0.89)	OPRM1OPRD1MRGPRX2OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5908927-A	Synthesis of deuterated opiate glucuronides	HIGH STANDARD PRODUCTS CORPORATION (US)	1999-06-01	—	—	US	claimed
US-5908927-A	Synthesis of deuterated opiate glucuronides	HIGH STANDARD PRODUCTS CORPORATION (US)	1999-06-01	—	—	US	disclosed