SCHEMBL8410334

SCHEMBL8410334

O=CNC1(CCc2ccccc2)CCCCC1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
ADRB2 P07550 2/20 0.39
HTT P42858 1/20 0.39
ADH1B P00325 1/20 0.38
ADH1C P00326 1/20 0.38
ADH1A P07327 1/20 0.38
ADH7 P40394 1/20 0.38
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
CYP3A4 P08684 1/20 0.37
CYP2C19 P33261 1/20 0.37
EPHX2 P34913 1/20 0.36
CTSB P07858 1/20 0.35
CTSS P25774 1/20 0.35
SIGMAR1 Q99720 2/20 0.35
EPHX1 P07099 1/20 0.35
TAAR1 Q96RJ0 1/20 0.35
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8409983 0.84 FKBP1A (0.37) ALDH1A1ADH1BADH1CADH1AADH7
SCHEMBL8059353 0.83 ADRB2 (0.50) ALDH1A1ADRB2HTTADH1BADH1C
SCHEMBL8070720 0.81 ADRB2 (0.48) ALDH1A1ADRB2HTTADH1BADH1C
SCHEMBL28742422 0.78 ATM (0.42) ALDH1A1ADRB2HTTKMT2AMEN1
SCHEMBL5071627 0.75 CYP1A2 (0.37) ALDH1A1KMT2AMEN1TAAR1
SCHEMBL18114513 0.68 OPRM1 (0.42) ALDH1A1SIGMAR1
SCHEMBL367356 0.68 DPP4 (0.57) KMT2AMEN1CYP3A4CYP2C19TAAR1
SCHEMBL17493640 0.68 OPRM1 (0.58) KMT2AMEN1SIGMAR1
SCHEMBL21058274 0.68 MAOA (0.50) SIGMAR1TAAR1
SCHEMBL4989701 0.68 OPRM1 (0.58) KMT2AMEN1SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5962469-A PREVENTION OF OXIDATION TISSUE DAMAGE BY FREE RADICALS HOECHST MARION ROUSSEL INC. (US) 1999-10-05 US disclosed
EP-0863878-A1 CYCLIC NITRONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM HOECHST MARION ROUSSEL, INC. (US) 1998-09-16 EP disclosed
WO-1997010218-A1 CYCLIC NITRONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM HOECHST MARION ROUSSEL, INC. (US) 1997-03-20 WO disclosed