Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8678573 | 0.83 | SIGMAR1 (0.49) | SIGMAR1OPRM1MEN1KMT2A | |
| SCHEMBL8416575 | 0.81 | SIGMAR1 (0.46) | LMNASIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8419906 | 0.81 | SIGMAR1 (0.41) | LMNAGAASIGMAR1OPRM1KCNH2 | |
| Potassium Ion SCHEMBL8416582 | 0.79 | CYP1A2 (0.39) | LMNAGAASIGMAR1OPRM1KCNH2 | |
| SCHEMBL8416911 | 0.79 | CYP1A2 (0.39) | LMNAGAASIGMAR1OPRM1KCNH2 | |
| SCHEMBL8419916 | 0.76 | OPRM1 (0.39) | SIGMAR1OPRM1KCNH2OPRL1ADRA1D | |
| SCHEMBL8416982 | 0.76 | KCNA3 (0.51) | OPRM1KCNH2ADRA1APOLB | |
| SCHEMBL6892997 | 0.73 | LMNA (0.53) | LMNAGAASIGMAR1OPRM1OPRL1 | |
| SCHEMBL7083719 | 0.72 | POLB (0.56) | SIGMAR1KCNH2POLB | |
| SCHEMBL7965697 | 0.70 | KCNA3 (0.57) | GAAOPRM1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849762-A | Peripherally acting anti-pruritic opiates | ADOLOR CORPORATION (US) | 1998-12-15 | — | — | US | claimed |
| US-5888494-A | TOPICAL | ADOLOR CORPORATION (US) | 1999-03-30 | — | — | US | disclosed |
| US-5849762-A | Peripherally acting anti-pruritic opiates | ADOLOR CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| US-5849761-A | Peripherally active anti-hyperalgesic opiates | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-15 | — | — | US | disclosed |