Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8416635 | 0.76 | LMNA (0.46) | OPRM1OPRL1SIGMAR1KCNH2ADRA1D | |
| Hydrochloric Acid SCHEMBL8419906 | 0.74 | SIGMAR1 (0.41) | OPRM1OPRL1SIGMAR1KCNH2ADRA1D | |
| SCHEMBL8416982 | 0.74 | KCNA3 (0.51) | OPRM1KCNH2ADRA1A | |
| Potassium Ion SCHEMBL8416582 | 0.73 | CYP1A2 (0.39) | OPRM1OPRL1SIGMAR1KCNH2ADRA1D | |
| SCHEMBL8416911 | 0.73 | CYP1A2 (0.39) | OPRM1OPRL1SIGMAR1KCNH2ADRA1D | |
| SCHEMBL7965697 | 0.71 | KCNA3 (0.57) | OPRM1ADRA1DADRA1AADRA1B | |
| SCHEMBL7083719 | 0.68 | POLB (0.56) | SIGMAR1KCNH2 | |
| SCHEMBL5960435 | 0.66 | HRH3 (0.50) | SIGMAR1 | |
| SCHEMBL5714434 | 0.65 | L3MBTL1 (0.63) | SIGMAR1 | |
| SCHEMBL6892997 | 0.65 | LMNA (0.53) | OPRM1OPRL1SIGMAR1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849762-A | Peripherally acting anti-pruritic opiates | ADOLOR CORPORATION (US) | 1998-12-15 | — | — | US | claimed |
| US-5888494-A | TOPICAL | ADOLOR CORPORATION (US) | 1999-03-30 | — | — | US | disclosed |
| US-5849762-A | Peripherally acting anti-pruritic opiates | ADOLOR CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| US-5849761-A | Peripherally active anti-hyperalgesic opiates | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-15 | — | — | US | disclosed |