Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8419906 | 0.86 | SIGMAR1 (0.41) | OPRM1ADRA1AKCNH2L3MBTL1 | |
| SCHEMBL8416911 | 0.84 | CYP1A2 (0.39) | KCNA3OPRM1ADRA1AKCNH2 | |
| Potassium Ion SCHEMBL8416582 | 0.84 | CYP1A2 (0.39) | KCNA3OPRM1ADRA1AKCNH2 | |
| SCHEMBL8416635 | 0.76 | LMNA (0.46) | POLBOPRM1ADRA1AKCNH2 | |
| SCHEMBL7965697 | 0.75 | KCNA3 (0.57) | KCNA3OPRD1OPRM1OPRK1ADRA1A | |
| SCHEMBL8419916 | 0.74 | OPRM1 (0.39) | OPRM1ADRA1AKCNH2 | |
| SCHEMBL7313939 | 0.68 | KCNA3 (1.00) | KCNA3OPRD1OPRM1OPRK1KDM4E | |
| SCHEMBL6197539 | 0.67 | KCNA3 (0.77) | KCNA3OPRD1OPRM1OPRK1SLC22A1 | |
| SCHEMBL7083719 | 0.66 | POLB (0.56) | POLBALDH1A1KCNH2L3MBTL1 | |
| SCHEMBL11708747 | 0.66 | KCNA3 (0.80) | KCNA3OPRD1OPRM1OPRK1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849762-A | Peripherally acting anti-pruritic opiates | ADOLOR CORPORATION (US) | 1998-12-15 | — | — | US | claimed |
| US-5888494-A | TOPICAL | ADOLOR CORPORATION (US) | 1999-03-30 | — | — | US | disclosed |
| US-5849762-A | Peripherally acting anti-pruritic opiates | ADOLOR CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| US-5849761-A | Peripherally active anti-hyperalgesic opiates | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-15 | — | — | US | disclosed |