Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 4/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | CTSA | P10619 | 2/20 | 0.44 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198138 | 0.87 | HDAC4 (0.56) | CYP17A1HDAC4HDAC2HDAC8CTSL | |
| SCHEMBL18092986 | 0.85 | HDAC4 (0.51) | CYP17A1HDAC4HDAC2HDAC8CTSL | |
| SCHEMBL8729744 | 0.85 | HDAC4 (0.51) | CYP17A1HDAC4HDAC2HDAC8CTSL | |
| SCHEMBL13725634 | 0.83 | EPHX2 (0.49) | CYP17A1HDAC4HDAC2HDAC8PRMT6 | |
| SCHEMBL84433 | 0.82 | RXRA (0.54) | CYP17A1HDAC4HDAC2HDAC8PRMT6 | |
| SCHEMBL14113522 | 0.81 | CTSK (0.47) | CYP17A1HDAC4HDAC2HDAC8CTSK | |
| SCHEMBL12303217 | 0.81 | CTSS (0.53) | CYP17A1PRMT6PRKCIKIF11CTSL | |
| SCHEMBL10025249 | 0.81 | EPHX2 (0.47) | CYP17A1HDAC4HDAC2HDAC8PRMT6 | |
| SCHEMBL14113264 | 0.80 | CYP17A1 (0.50) | CYP17A1KIF11CYP3A4CYP19A1CYP11B1 | |
| SCHEMBL9656296 | 0.79 | PTGS2 (0.48) | CYP17A1HDAC4HDAC2HDAC8RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142369-A1 | Combination of an H3 antagonist/inverse agonist and an appetite suppressant | SCHERING CORPORATION | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142369-A1 | Combination of an H3 antagonist/inverse agonist and an appetite suppressant | CNR2, GPR119, GLP1R | CYP17A1 783/4885HDAC4 245/4885HDAC2 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.