Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.42 |
| ▸ | CDK9 | P50750 | 4/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.38 |
| ▸ | PRKCA | P17252 | 6/20 | 0.34 |
| ▸ | PRKCB | P05771 | 2/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950830 | 0.78 | CCNE2 (0.58) | CDK2GSK3BPRKCAPRKCBPRKCH | |
| SCHEMBL8466339 | 0.71 | CCNT1 (0.44) | CCNT1CDK9CDK2CCNA2PTPRC | |
| SCHEMBL8619764 | 0.70 | CAMK2D (0.57) | CCNT1CDK9CDK2CCNA2PTPRC | |
| SCHEMBL8920747 | 0.70 | PRKCG (0.61) | CCNT1CDK9CDK2CCNA2PTPRC | |
| SCHEMBL6945284 | 0.69 | CCNE2 (0.67) | CDK2GSK3BPRKCAPRKCBPRKCH | |
| SCHEMBL5957039 | 0.69 | GSK3B (0.53) | CCNT1CDK9CDK2CCNA2PTPRC | |
| SCHEMBL29447190 | 0.69 | GSK3B (0.53) | CCNT1CDK9CDK2CCNA2PTPRC | |
| SCHEMBL25282614 | 0.68 | CAMK2D (0.57) | CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL8923158 | 0.68 | GSK3B (0.47) | CCNT1CDK9CDK2CCNA2GSK3B | |
| SCHEMBL8477960 | 0.67 | CCNT1 (0.42) | CCNT1CDK9CDK2CCNA2PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856517-A | ANTIPROLIFERATIVE AGENTS USEFUL IN THE TREATMENT OF CANCER. | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |