Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.46 |
| ▸ | ITGAV | P06756 | 11/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.42 |
| ▸ | PTGIR | P43119 | 5/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | C1R | P00736 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430878 | 0.80 | CA12 (0.39) | — | |
| SCHEMBL8431123 | 0.79 | ITGB3 (0.54) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL8429288 | 0.71 | CA2 (0.38) | F2KLKB1PRSS1 | |
| SCHEMBL8432878 | 0.70 | ITGB3 (0.39) | ITGB3ITGAVITGA2B | |
| SCHEMBL8432271 | 0.70 | ACHE (0.33) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL8429051 | 0.68 | SIRT2 (0.36) | F2F10PRSS1 | |
| SCHEMBL8431173 | 0.67 | CTSD (0.35) | F2KLKB1PRSS1 | |
| SCHEMBL11168815 | 0.66 | ADRA2A (0.66) | PTGIRADRA2A | |
| SCHEMBL7863191 | 0.65 | KMT2A (0.47) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| Hydrochloric Acid SCHEMBL11160123 | 0.65 | ADRA2A (0.64) | PTGIRADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |