Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.37 |
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | CA4 | P22748 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.32 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430809 | 0.92 | CA1 (0.32) | CA1CA2CA4KMT2AALDH1A1 | |
| SCHEMBL8429290 | 0.89 | CA1 (0.33) | CA1CA2CA4KMT2AALDH1A1 | |
| SCHEMBL8429052 | 0.85 | PPARG (0.34) | CA1CA2CA4KMT2A | |
| SCHEMBL8431435 | 0.85 | CA1 (0.32) | CA1CA2CA4KMT2AALDH1A1 | |
| SCHEMBL8431176 | 0.84 | UBE2M (0.34) | CA1CA2CA4ALDH1A1TSHR | |
| SCHEMBL8430969 | 0.80 | NR1H4 (0.33) | KMT2AALDH1A1LMNAGAAMEN1 | |
| SCHEMBL8521199 | 0.80 | ALDH1A1 (0.36) | CA1CA2KMT2AALDH1A1LMNA | |
| SCHEMBL8430873 | 0.79 | KMT2A (0.32) | KMT2AMEN1SMN1; SMN2RXFP1 | |
| SCHEMBL8429158 | 0.78 | ITGB3 (0.44) | F2 | |
| SCHEMBL8429048 | 0.78 | DHODH (0.36) | CA1CA2KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |