Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436848 | 0.85 | ADRA2A (0.44) | MTNR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8521222 | 0.82 | ADRA2A (0.46) | MTNR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8433848 | 0.80 | MTNR1A (0.67) | MTNR1ANQO2MTNR1B | |
| Oxalic Acid SCHEMBL8432164 | 0.80 | ADRA2A (0.43) | MTNR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8432229 | 0.76 | MTNR1A (0.39) | MTNR1AOPRD1 | |
| SCHEMBL8432175 | 0.75 | MTNR1A (0.39) | MTNR1AOPRD1 | |
| Dimethylamine SCHEMBL8433452 | 0.74 | OPRD1 (0.38) | MTNR1AADRA2AADRA2BADRA2COPRD1 | |
| SCHEMBL9628347 | 0.74 | ESR1 (0.60) | MTNR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7101452 | 0.74 | ACHE (0.42) | MTNR1AOPRD1 | |
| SCHEMBL7950364 | 0.73 | MTNR1A (0.41) | MTNR1AHTR6NQO2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972964-A | FOR TREATMENT OF CERTAIN PSYCHIC AND NEUROLOGIC DISORDERS SUCH AS PSYCHOSIS, ANXIETY DISORDERS, PANIC DISORDER, OBSESSIVE COMPULSIVE DISORDER, DEPRESSION, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, AGGRESSION | H. LUNDBECK A/S (DK) | 1999-10-26 | — | — | US | disclosed |
| US-5807889-A | PSYCHOLOGICAL AND NERVOUS SYSTEM DISORDERS | H. LUNDBECK A/S (DK) | 1998-09-15 | — | — | US | disclosed |
| EP-0673360-B1 | AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES | LUNDBECK & CO AS H (DK) | 1998-08-26 | — | — | EP | disclosed |
| EP-0673360-A1 | AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES | H. LUNDBECK A/S (DK) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994013620-A1 | AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES | H. LUNDBECK A/S (DK) | 1994-06-23 | — | — | WO | disclosed |