Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 5/20 | 0.32 |
| ▸ | HTR2C | P28335 | 5/20 | 0.32 |
| ▸ | HTR2B | P41595 | 4/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436852 | 0.88 | MTNR1A (0.38) | OPRD1MTNR1AADRA2AHTR1A | |
| Oxalic Acid SCHEMBL8432169 | 0.82 | MTNR1A (0.39) | OPRD1MTNR1A | |
| SCHEMBL7101452 | 0.78 | ACHE (0.42) | OPRD1MTNR1A | |
| Dimethylamine SCHEMBL8433853 | 0.78 | MTNR1A (0.59) | MTNR1AALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL8521222 | 0.75 | ADRA2A (0.46) | OPRD1MTNR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8433448 | 0.74 | MTNR1A (0.43) | OPRD1MTNR1AADRA2AADRA2BADRA2C | |
| SCHEMBL5969884 | 0.74 | CA12 (0.48) | MTNR1AKDM4EMAPTRAB9AHTR2A | |
| SCHEMBL20283376 | 0.72 | ALDH1A1 (0.38) | ALDH1A1KDM4EMAPTHPGDRAB9A | |
| SCHEMBL14846079 | 0.71 | PFKFB3 (0.38) | HTR2AHTR2CHTR2BADRA2AADRB1 | |
| SCHEMBL8436848 | 0.71 | ADRA2A (0.44) | MTNR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972964-A | FOR TREATMENT OF CERTAIN PSYCHIC AND NEUROLOGIC DISORDERS SUCH AS PSYCHOSIS, ANXIETY DISORDERS, PANIC DISORDER, OBSESSIVE COMPULSIVE DISORDER, DEPRESSION, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, AGGRESSION | H. LUNDBECK A/S (DK) | 1999-10-26 | — | — | US | disclosed |
| US-5807889-A | PSYCHOLOGICAL AND NERVOUS SYSTEM DISORDERS | H. LUNDBECK A/S (DK) | 1998-09-15 | — | — | US | disclosed |
| EP-0673360-B1 | AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES | LUNDBECK & CO AS H (DK) | 1998-08-26 | — | — | EP | disclosed |
| EP-0673360-A1 | AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES | H. LUNDBECK A/S (DK) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994013620-A1 | AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES | H. LUNDBECK A/S (DK) | 1994-06-23 | — | — | WO | disclosed |