Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440844 | 0.89 | MAPT (0.37) | ALDH1A1MAPTDPP8DPP9ATM | |
| SCHEMBL9574265 | 0.82 | DPP8 (0.40) | ALDH1A1MAPTDPP8DPP9GAA | |
| SCHEMBL8439011 | 0.78 | ATM (0.38) | ALDH1A1MAPTCCR5ATMHPGD | |
| SCHEMBL5669278 | 0.78 | SIGMAR1 (0.35) | ALDH1A1DPP8DPP9CCR5 | |
| SCHEMBL8435822 | 0.76 | CCR5 (0.39) | ALDH1A1CCR5 | |
| SCHEMBL8436096 | 0.75 | CCR5 (0.39) | ALDH1A1CCR5 | |
| SCHEMBL8440761 | 0.75 | CCR5 (0.39) | ALDH1A1CCR5 | |
| SCHEMBL9877400 | 0.75 | RAB9A (0.45) | ALDH1A1MAPTRAB9A | |
| SCHEMBL8436425 | 0.73 | MCHR1 (0.39) | ALDH1A1MAPTCCR5ATMHPGD | |
| SCHEMBL8448811 | 0.72 | ALDH1A1 (0.34) | ALDH1A1DPP8DPP9CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866564-A | STABILITY | SANKYO COMPANY, LIMITED (JP) | 1999-02-02 | — | — | US | disclosed |
| US-5712267-A | Carbapenem derivatives, their preparation and their use as antibiotics | SANKYO COMPANY,. LIMITED (JP) | 1998-01-27 | — | — | US | disclosed |
| EP-0560613-A1 | Antimicrobial carbapenem derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1993-09-15 | — | — | EP | disclosed |