SCHEMBL843955

SCHEMBL843955

O=Cc1cnc2ccccc2c1Cl

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 2/20 0.50
MAOA P21397 1/20 0.45
MAOB P27338 1/20 0.45
KDM4E B2RXH2 3/20 0.42
GPR3 P46089 1/20 0.42
PDE4A P27815 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4C Q08493 1/20 0.41
PDE4D Q08499 1/20 0.41
KMT2A Q03164 4/20 0.40
MEN1 O00255 3/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
ALOX15 P16050 2/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
HSD17B10 Q99714 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18874674 0.98 ERN1 (0.49) ERN1MAOAMAOBKDM4EGPR3
SCHEMBL25229015 0.84 TDP1 (0.50) ERN1ALDH1A1CYP1A2LMNATDP1
SCHEMBL2718596 0.81 MAOA (0.45) ERN1MAOAMAOBKDM4EGPR3
SCHEMBL3409403 0.79 KDM4E (0.56) ERN1KDM4EKMT2AMEN1L3MBTL1
SCHEMBL5150835 0.78 ERN1 (0.50) ERN1MAOAKDM4EGPR3KMT2A
SCHEMBL22744411 0.78 ERN1 (0.50) ERN1KDM4EGPR3KMT2AMEN1
SCHEMBL29955644 0.78 ERN1 (0.59) ERN1KDM4EGPR3KMT2AMEN1
SCHEMBL22721434 0.78 ERN1 (0.50) ERN1KDM4EGPR3KMT2AMEN1
SCHEMBL11504978 0.78 ERN1 (0.59) ERN1KDM4EGPR3KMT2AMEN1
SCHEMBL5046238 0.77 ALDH1A1 (0.47) KDM4EKMT2AMEN1L3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12559504-B2 Benzotriazole derivative UBE CORPORATION (JP) 2026-02-24 US disclosed
EP-3978073-B1 1H-BENZO[D][1,2,3]TRIAZOLE DERIVATIVES AS KEAP1 INHIBITORS FOR THE TREATMENT OF RENAL DISEASES UBE CORP (JP) 2025-10-15 EP disclosed
US-20250313561-A1 NEXT-GENERATION MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) RYVU THERAPEUTICS S A (PL) 2025-10-09 US disclosed
US-12344606-B2 Next-generation modulators of stimulator of interferon genes (STING) Ryvu Therapeutics S.A. (PL) 2025-07-01 US disclosed
CN-114174289-B Benzotriazole derivatives UBE株式会社 2025-03-07 CN disclosed
US-20250011319-A1 SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF LOMOND THERAPEUTICS, INC. 2025-01-09 US disclosed
US-12162863-B2 Modulators of stimulator of interferon genes (STING) Ryvu Therapeutics S.A. (PL) 2024-12-10 US disclosed
CN-118324761-A USP inhibitor, preparation method and application thereof 北京华森英诺生物科技有限公司 2024-07-12 CN disclosed
CN-118076605-A Substituted 1H-pyrazolo [4,3-c ] quinolines, methods of preparation and uses thereof 洛蒙治疗公司 2024-05-24 CN disclosed
EP-3983078-B1 NEXT-GENERATION MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) RYVU THERAPEUTICS S A (PL) 2023-11-15 EP disclosed
US-9040538-B2 Pyrimidines as novel therapeutic agents UNIVERSITE LAVAL (CA) 2015-05-26 US disclosed
EP-2432776-A1 METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS Chlorion Pharma, Inc. (CA) 2012-03-28 EP disclosed
US-20100298336-A1 PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS UNIVERSITE LAVAL (CA) 2010-11-25 US disclosed
US-20100298336-A1 PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS UNIVERSITE LAVAL (CA) 2010-11-25 US disclosed
US-20100298336-A1 PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS UNIVERSITE LAVAL (CA) 2010-11-25 US disclosed
WO-2010132999-A1 METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS CHLORION PHARMA, INC. (CA) 2010-11-25 WO disclosed
US-20100022570-A1 NOVEL MICROBIOCIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-01-28 US disclosed
US-20100022570-A1 NOVEL MICROBIOCIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-01-28 US disclosed
EP-2018367-B1 NOVEL MICROBIOCIDES SYNGENTA PARTICIPATIONS AG (CH) 2009-11-18 EP disclosed
WO-2007134799-A1 NOVEL MICROBIOCIDES SYNGENTA PARTICIPATIONS AG (CH) 2007-11-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298336-A1 PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS TYMS, P2RX2, TYMP ERN1 908/4885MAOA 1192/4885MAOB 388/4885
US-12559504-B2 Benzotriazole derivative KEAP1, NFE2L2, NCOR1 ERN1 3021/4885MAOA 596/4885MAOB 548/4885
US-12344606-B2 Next-generation modulators of stimulator of interferon genes (STING) STING1, IRF3, CGAS ERN1 810/4885MAOA 1056/4885MAOB 1099/4885
US-12162863-B2 Modulators of stimulator of interferon genes (STING) STING1, IRF3, CGAS ERN1 1276/4885MAOA 747/4885MAOB 730/4885
US-20250011319-A1 SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF FLT3, PDXK, PHKG1 ERN1 1252/4885MAOA 3705/4885MAOB 3127/4885
US-20100022570-A1 NOVEL MICROBIOCIDES QSOX1, MSR1, NOX1 ERN1 3732/4885MAOA 1543/4885MAOB 1096/4885
US-20250313561-A1 NEXT-GENERATION MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) STING1, IRF3, CGAS ERN1 810/4885MAOA 1056/4885MAOB 1099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.