Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PHGDH | O43175 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13210703 | 0.80 | RAB9A (0.65) | LMNANPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL23200368 | 0.80 | KCNMA1 (0.58) | LMNAKMT2AALDH1A1GAAHTT | |
| SCHEMBL8306313 | 0.79 | AKR1C2 (0.65) | LMNAKMT2AHCAR3MAPTALDH1A1 | |
| SCHEMBL8305753 | 0.78 | SMN1; SMN2 (0.74) | LMNANPC1RAB9AKMT2AHCAR3 | |
| SCHEMBL8307686 | 0.78 | ALOX5 (0.68) | LMNANPC1RAB9AKMT2AHCAR3 | |
| SCHEMBL300146 | 0.78 | ALDH1A1 (0.62) | LMNANPC1RAB9AKMT2AHCAR3 | |
| SCHEMBL8308004 | 0.77 | MEN1 (0.69) | KMT2AMAPTALDH1A1GAAPDE5A | |
| SCHEMBL7010635 | 0.77 | KCNMA1 (0.57) | LMNANPC1RAB9AKMT2AMAPT | |
| SCHEMBL95300 | 0.76 | RAB9A (0.58) | LMNANPC1RAB9AKMT2AMAPT | |
| SCHEMBL8303947 | 0.76 | ALDH1A1 (0.71) | LMNANPC1RAB9AKMT2AHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |