Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8448904 | 0.89 | DUT (0.44) | CYP2C9MMP2MMP9MMP8MMP13 | |
| SCHEMBL28758085 | 0.75 | ADAMTS5 (0.52) | ADAMTS5ADAMTS4MMP2MMP9MMP8 | |
| SCHEMBL27642228 | 0.75 | ADAMTS5 (0.52) | ADAMTS5ADAMTS4MMP2MMP9MMP8 | |
| SCHEMBL28171647 | 0.73 | ADAMTS5 (0.50) | ADAMTS5ADAMTS4MMP2MMP9KMT2A | |
| SCHEMBL8448898 | 0.72 | MMP9 (0.35) | ADAMTS5ADAMTS4CYP2C9MMP2MMP9 | |
| SCHEMBL8446545 | 0.71 | ADAMTS4 (0.48) | ADAMTS5ADAMTS4CYP2C9MMP9MMP13 | |
| SCHEMBL8837620 | 0.71 | CA12 (0.65) | LIMK2KMT2ATSHR | |
| SCHEMBL19953661 | 0.70 | POLQ (0.49) | CYP2C9POLQALDH1A1KMT2ATP53 | |
| SCHEMBL600070 | 0.69 | ADAMTS5 (0.51) | ADAMTS5ADAMTS4MMP13ESR1 | |
| SCHEMBL15904171 | 0.68 | ADAMTS5 (0.67) | ADAMTS5ADAMTS4MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915086-A1 | PHENYLSULFONAMIDE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-05-12 | — | — | EP | claimed |
| EP-0915086-A1 | PHENYLSULFONAMIDE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-05-12 | — | — | EP | disclosed |