SCHEMBL8446545

SCHEMBL8446545

C#Cc1ccc(S(=O)(=O)N(C)[C@H](C)C(=O)O)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADAMTS4 O75173 1/20 0.48
CYP2C9 P11712 4/20 0.45
MMP1 P03956 2/20 0.44
MMP9 P14780 2/20 0.44
MMP13 P45452 2/20 0.44
ADAM17 P78536 2/20 0.44
CA12 O43570 2/20 0.43
CA1 P00915 2/20 0.43
CA9 Q16790 2/20 0.43
CA2 P00918 1/20 0.43
CA4 P22748 1/20 0.43
CA14 Q9ULX7 1/20 0.43
KEAP1 Q14145 2/20 0.39
NFE2L2 Q16236 1/20 0.39
AGER Q15109 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
ADAMTS5 Q9UNA0 1/20 0.39
TAS2R14 Q9NYV8 1/20 0.38
BMP1 P13497 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8445657 0.85 MMP9 (0.48) ADAMTS4MMP1MMP9MMP13ADAM17
SCHEMBL8445813 0.84 MMP9 (0.62) ADAMTS4CYP2C9MMP1MMP9MMP13
SCHEMBL8445759 0.84 MMP9 (0.54) ADAMTS4MMP1MMP9MMP13ADAM17
SCHEMBL10911759 0.82 AGER (0.59) ADAMTS4MMP1MMP9MMP13CA12
SCHEMBL14798295 0.82 ADAMTS4 (0.58) ADAMTS4MMP9MMP13KEAP1NFE2L2
SCHEMBL12907960 0.82 ADAMTS4 (0.58) ADAMTS4MMP9MMP13KEAP1NFE2L2
SCHEMBL16894216 0.81 ADAMTS4 (0.50) ADAMTS4MMP1MMP9MMP13KEAP1
SCHEMBL16894214 0.81 ADAMTS4 (0.50) ADAMTS4MMP1MMP9MMP13KEAP1
SCHEMBL8446538 0.79 MMP13 (0.44) ADAMTS4MMP1MMP9MMP13ADAM17
SCHEMBL26679674 0.77 CA12 (0.59) MMP1MMP9MMP13CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0915086-A1 PHENYLSULFONAMIDE DERIVATIVES ONO PHARMACEUTICAL CO., LTD. (JP) 1999-05-12 EP claimed
EP-0915086-A1 PHENYLSULFONAMIDE DERIVATIVES ONO PHARMACEUTICAL CO., LTD. (JP) 1999-05-12 EP disclosed