SCHEMBL8459014

SCHEMBL8459014

CCOC(OC)Oc1cc(C23CC4CC(CC(C4)C2)C3)cc(-c2cccc3ccccc23)c1O

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.31
HIF1A Q16665 1/20 0.31
FDPS P14324 1/20 0.31
AVPR2 P30518 1/20 0.30
AVPR1A P37288 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8458190 0.83 DEGS1 (0.35) CNR2HIF1A
SCHEMBL8457350 0.80 EPHX2 (0.36) CNR2HIF1A
SCHEMBL8458442 0.77 IKBKB (0.42) CNR2HIF1AAVPR2AVPR1A
SCHEMBL8911209 0.71 RARA (0.41) CNR2AVPR2AVPR1A
SCHEMBL8458240 0.70 RARB (0.32) HIF1A
SCHEMBL8458440 0.70 RARB (0.40)
SCHEMBL8459321 0.69 RARB (0.39)
SCHEMBL8909355 0.66 MEN1 (0.42) CNR2
SCHEMBL8458292 0.66 IKBKB (0.41) CNR2HIF1A
SCHEMBL8457476 0.66 RARB (0.44) CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5952382-A INHIBITING THE BIOLOGICAL EFFECTS OF AN OVERREGULATION OF RETINOID ACID RECEPTORS AND/OR OF A HYPERVITAMINOSIS A; TREATING SKIN DISORDER, EYE VISION DEFECTS, SKIN AGING CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1999-09-14 US disclosed