SCHEMBL8467655

SCHEMBL8467655

CN(C)c1ccc(Nc2ccc(N3C(=O)C=CC3=O)cc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.64
MGLL Q99685 14/20 0.52
FAAH O00519 5/20 0.52
MAPK1 P28482 3/20 0.44
NPSR1 Q6W5P4 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
PKM P14618 1/20 0.44
ALDH1A1 P00352 3/20 0.44
GAA P10253 3/20 0.44
MAPT P10636 3/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
KDM4E B2RXH2 1/20 0.44
RECQL P46063 1/20 0.44
GALR2 O43603 1/20 0.42
NSD2 O96028 1/20 0.42
LMNA P02545 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3759716 0.89 MGLL (0.65) HSP90AA1MGLLFAAHMAPK1NPSR1
SCHEMBL12321793 0.85 HSP90AA1 (0.84) HSP90AA1MGLLFAAHMAPK1NPSR1
SCHEMBL8467244 0.80 MGLL (0.77) HSP90AA1MGLLFAAHMAPK1NPSR1
SCHEMBL5150580 0.79 MGLL (0.52) MGLLFAAHMAPK1NPSR1TDP1
SCHEMBL458382 0.79 MGLL (0.52) HSP90AA1MGLLFAAHMAPK1NPSR1
SCHEMBL4289960 0.79 MGLL (0.52) HSP90AA1MGLLFAAHMAPK1NPSR1
SCHEMBL571682 0.78 HSP90AA1 (1.00) HSP90AA1MGLLFAAHMAPK1NPSR1
SCHEMBL3665727 0.77 MGLL (0.65) HSP90AA1MGLLFAAHMAPK1NPSR1
SCHEMBL222247 0.77 ALDH1A1 (0.65) MAPK1NPSR1TDP1ALDH1A1GAA
SCHEMBL9479616 0.77 ALDH1A1 (0.65) MAPK1NPSR1TDP1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5936038-A MIXTURE CONTAINING ELASTOMER HAVING PENDANT REACTIVE AMINE GROUP AND PHENOLIC RESIN CURATIVE THE UNIVERSITY OF AKRON (US) 1999-08-10 US claimed
US-5936038-A MIXTURE CONTAINING ELASTOMER HAVING PENDANT REACTIVE AMINE GROUP AND PHENOLIC RESIN CURATIVE THE UNIVERSITY OF AKRON (US) 1999-08-10 US disclosed
EP-0570825-B1 Tire sidewall composition containing silica having low PH GOODYEAR TIRE & RUBBER (US) 1996-08-07 EP disclosed
EP-0475215-B1 Carboxylic acid esters with thio groups GOODYEAR TIRE & RUBBER (US) 1994-10-19 EP disclosed
EP-0570825-A1 Tire sidewall composition containing silica having low PH THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-11-24 EP disclosed
US-5244028-A Natural rubber or polybutadiene, silica, antidegradation agent, carbon black THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-09-14 US disclosed
US-5216049-A A phenolic or amine stabilizer and an organothioalkylene styrene bound to a polymer; aging resistance; rubbers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-06-01 US disclosed
EP-0475215-A1 Carboxylic acid esters with thio groups THE GOODYEAR TIRE & RUBBER COMPANY (US) 1992-03-18 EP disclosed
US-5069819-A SYNERGISTS FOR CONVENTIONAL PHENOLIC AND AMINE ANTIOXIDANTS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-12-03 US disclosed