Biphenyl

Biphenyl

SCHEMBL8467751

Nc1nc(N)nc(N)n1.O=P(O)(O)O.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 7/20 0.58
ADORA2A P29274 7/20 0.58
ADORA3 P0DMS8 2/20 0.58
ADORA2B P29275 2/20 0.58
POLB P06746 1/20 0.58
ACP3 P15309 2/20 0.45
PTPN5 P54829 1/20 0.44
NUDT1 P36639 1/20 0.44
DHFR P00374 1/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43
KDM4E B2RXH2 1/20 0.42
HSP90AA1 P07900 1/20 0.42
HSP90AB1 P08238 1/20 0.42
TDP1 Q9NUW8 2/20 0.42
CYP3A4 P08684 1/20 0.42
TAAR1 Q96RJ0 1/20 0.42
HSD17B10 Q99714 1/20 0.42
MEN1 O00255 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL183386 0.85 ADORA2A (0.75) ADORA1ADORA2AADORA3ADORA2BPOLB
Phosphoric Acid SCHEMBL27912504 0.83 ADORA3 (0.43) ADORA1ADORA2AADORA3ADORA2BPOLB
Biphenyl SCHEMBL27485598 0.83 ALDH1A1 (0.60) ACP3PTPN5MMP8MMP14CA14
Biphenyl SCHEMBL263925 0.83 ALDH1A1 (0.60) ACP3PTPN5MMP8MMP14CA14
Biphenyl SCHEMBL342228 0.83 ALDH1A1 (0.60) ACP3PTPN5MMP8MMP14CA14
Biphenyl SCHEMBL3727875 0.83 ALDH1A1 (0.60) ACP3PTPN5MMP8MMP14CA14
Biphenyl SCHEMBL3763955 0.83 ALDH1A1 (0.60) ACP3PTPN5MMP8MMP14CA14
Biphenyl SCHEMBL1945860 0.83 ALDH1A1 (0.60) ACP3PTPN5MMP8MMP14CA14
Biphenyl SCHEMBL27822260 0.80 ACP3 (0.52) ACP3PTPN5TDP1CYP3A4TAAR1
SCHEMBL29662830 0.80 CA2 (0.50) ADORA1ADORA2AADORA3ADORA2BPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250230558-A1 ELECTROCHEMICAL CELL FOR CONVERSION OF CARBON DIOXIDE AND A STACK INCLUDING THE SAME KIA CORPORATION (KR) 2025-07-17 US disclosed
US-20250230559-A1 ELECTROCHEMICAL CELL FOR CONVERSION OF CARBON DIOXIDE AND A STACK INCLUDING THE SAME KIA CORPORATION (KR) 2025-07-17 US disclosed
EP-4585719-A1 AN ELECTROCHEMICAL CELL FOR CONVERSION OF CARBON DIOXIDE AND A STACK INCLUDING THE SAME Hyundai Motor Company (KR) 2025-07-16 EP disclosed
EP-4585718-A1 AN ELECTROCHEMICAL CELL FOR CONVERSION OF CARBON DIOXIDE AND A STACK INCLUDING THE SAME Hyundai Motor Company (KR) 2025-07-16 EP disclosed
US-5936048-A Method for preparing modified resins and their applications MITSUI CHEMICALS, INC. (JP) 1999-08-10 US disclosed
US-5869184-A RESIN RAW MATERIALS FOR PAINTS, ADHESIVES MITSUI TOATSU CHEMICALS, INC. (JP) 1999-02-09 US disclosed
EP-0698620-B1 Method for preparing modified resins and their applications MITSUI CHEMICALS INC (JP) 1998-12-09 EP disclosed
US-5792814-A REACTING A RESIN WITH A 5-((4,6-DIAMINO-S-TRIAZIN-2-YL)-NORBORN-2-ENE AND REACTING WITH AN EPOXIDE; FIREPROOFING; MOLDING MATERIALS MITSUI CHEMICALS, INC. (JP) 1998-08-11 US disclosed
US-5744504-A AMINO RESIN; THERMOSETTING MOLDING MATERIALS MITSUI TOATSU CHEMICALS, INC. (JP) 1998-04-28 US disclosed
US-5674947-A HEATING RESIN WITH FUNCTIONALIZED NORBORNENE COMPOUND IN ABSENCE OF REACTION CATALYST OR INITIATOR MITSUI TOATSU CHEMICALS, INC. (JP) 1997-10-07 US disclosed
US-5648446-A ADHESIVES, FIREPROOFING, HEAT RESISTANCE IN RESINS FOR MOLDING MATERIALS MITSUI TOATSU CHEMICALS, INC. (JP) 1997-07-15 US disclosed
US-5646240-A THERMOSETTING MOLDING COMPOSITIONS MITSUI TOATSU CHEMICALS, INC. (JP) 1997-07-08 US disclosed
US-5596039-A FLAME RETARDERS, HEAT RESISTANCE MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1997-01-21 US disclosed
US-5569726-A USEFUL IN FLAME-RETARDING, THERMAL STABILIZATION AND COMPATIBILIZATION OF RESINS AND IN THERMOSETTING MOLDING COMPOSITIONS MITSUI TOATSU CHEMICALS, INC. (JP) 1996-10-29 US disclosed
US-5545702-A THERMOSETTING RESIN COMPOSITION MITSUI TOATSU CHEMICALS, INC. (JP) 1996-08-13 US disclosed
US-5536795-A ADHESIVES AND PAINTS AND FIREPROOFING THERMOSETTING RESINS MITSUI TOATSU CHEMICALS, INC. (JP) 1996-07-16 US disclosed
EP-0698620-A1 Method for preparing modified resins and their applications MITSUI TOATSU CHEMICALS, Inc. (JP) 1996-02-28 EP disclosed
US-5480947-A N-METHYLOL DIGUANAMINES MITSUI TOATSU CHEMICALS, INC. (JP) 1996-01-02 US disclosed
EP-0612797-A2 Modification method of resins MITSUI TOATSU CHEMICALS, Inc. (JP) 1994-08-31 EP disclosed