Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CDC42 | P60953 | 1/20 | 0.58 |
| ▸ | RAC1 | P63000 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naproxol SCHEMBL10395753 | 1.00 | ABCB11 (1.00) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| Naproxol SCHEMBL30599771 | 1.00 | ABCB11 (1.00) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| Naproxol SCHEMBL43203 | 1.00 | ABCB11 (1.00) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| Naproxol SCHEMBL29979997 | 1.00 | ABCB11 (1.00) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11015086 | 0.97 | ABCB11 (0.93) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| Naproxol SCHEMBL9451481 | 0.91 | ABCB11 (0.82) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL9009741 | 0.84 | ABCB11 (0.72) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL28346869 | 0.84 | ABCB11 (0.72) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL14783039 | 0.83 | ABCB11 (0.71) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11806102 | 0.83 | ABCB11 (0.71) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12421200-B2 | Manganese-catalysed hydrogenation of esters | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2025-09-23 | — | — | US | disclosed |
| CN-118215461-A | Compositions and methods for reducing pigmentation | 总医院公司 | 2024-06-18 | — | — | CN | disclosed |
| EP-3737663-B1 | MANGANESE-CATALYSED HYDROGENATION OF ESTERS | UNIV COURT UNIV ST ANDREWS (GB) | 2023-02-22 | — | — | EP | disclosed |
| CN-115160123-A | Method for preparing carboxylic acid compound by oxidizing alcohol with oxygen as oxidant under catalysis of copper | 复旦大学 | 2022-10-11 | — | — | CN | disclosed |
| WO-2022206399-A1 | COPPER CATALYSIS-BASED METHOD FOR PREPARING CARBOXYLIC ACID COMPOUND BY MEANS OF ALCOHOL OXIDATION USING OXYGEN AS OXIDANT | 复旦大学 | 2022-10-06 | — | — | WO | disclosed |
| US-20210053932-A1 | MANGANESE-CATALYSED HYDROGENATION OF ESTERS | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2021-02-25 | — | — | US | disclosed |
| EP-3737663-A1 | MANGANESE-CATALYSED HYDROGENATION OF ESTERS | University Court of The University of St Andrews (GB) | 2020-11-18 | — | — | EP | disclosed |
| CN-111587238-A | Manganese catalyzed ester hydrogenation | 圣安德鲁斯大学董事会 | 2020-08-25 | — | — | CN | disclosed |
| CN-104402919-A | Method for synthesis of chiral pinacol boron ester compound | UNIV ZHEJIANG | 2015-03-11 | — | — | CN | disclosed |
| CN-101486643-B | Trans naproxen ester, optical isomer thereof, as well as preparation and use thereof | UNIV HUNAN | 2012-08-15 | — | — | CN | disclosed |
| US-5273993-A | Antiarthritic agents; osteoporosis | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-12-28 | — | — | US | disclosed |
| US-5194446-A | Antiarthritic agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-03-16 | — | — | US | disclosed |
| US-5192785-A | Sulfamates as antiglaucoma agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-03-09 | — | — | US | disclosed |
| US-4980291-A | TRANSESTERIFICATION IN PRESENCE OF FREE OR IMMOBILIZED PSEUDOMONOS FLUORESCENS OR HYDROLASES | ISTITUTO GUIDO DONEGANI S.P.A. (IT) | 1990-12-25 | — | — | US | disclosed |
| EP-0403185-A2 | Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-12-19 | — | — | EP | disclosed |
| EP-0386848-A1 | Novel Exophiala species | GIST-BROCADES N.V. (NL) | 1990-09-12 | — | — | EP | disclosed |
| EP-0328125-A2 | Process for the enzymatic separation of the optical isomers of racemic alpha-alkyl-substituted primary alcohols | ISTITUTO GUIDO DONEGANI S.p.A. (IT) | 1989-08-16 | — | — | EP | disclosed |
| US-4820717-A | Antimicrobial aromatic derivatives substituted by an (omega amino) alkanol group and compositions containing them | SANOFI (FR) | 1989-04-11 | — | — | US | disclosed |
| US-4243665-A | ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | SYNTHELABO (FR) | 1981-01-06 | — | — | US | disclosed |
| US-3958012-A | ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITY | SYNTEX CORPORATION (US) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12421200-B2 | Manganese-catalysed hydrogenation of esters | ADH5, HDHD5, ADH1A | ABCB11 2228/4885AKR1C3 1642/4885AKR1C2 1320/4885 |
| US-20210053932-A1 | MANGANESE-CATALYSED HYDROGENATION OF ESTERS | ADH5, HDHD5, ADH1A | ABCB11 2228/4885AKR1C3 1642/4885AKR1C2 1320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.