Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479733 | 0.90 | ALDH1A1 (0.45) | ALDH1A1HPGDGAACYP3A4CYP2C9 | |
| SCHEMBL8485493 | 0.87 | ALDH1A1 (0.44) | ALDH1A1HPGDGAAMAPTKDM4E | |
| SCHEMBL8855171 | 0.86 | HTT (0.45) | ALDH1A1HPGDGAAKDM4EGLA | |
| SCHEMBL9093965 | 0.84 | KEAP1 (0.41) | ALDH1A1HPGDGAACYP1A2MAPT | |
| SCHEMBL8606406 | 0.84 | LMNA (0.48) | ALDH1A1HPGDGAAMAPTLMNA | |
| SCHEMBL8608850 | 0.80 | KDM4E (0.43) | ALDH1A1HPGDGAACYP2C9KDM4E | |
| SCHEMBL9094581 | 0.73 | GRIK1 (0.48) | ALDH1A1HPGDGAAKDM4EGLA | |
| SCHEMBL9094525 | 0.73 | KDM4E (0.46) | ALDH1A1HPGDGAAKDM4EGLA | |
| SCHEMBL29698713 | 0.71 | ALDH1A1 (0.44) | ALDH1A1HPGDGAACYP1A2MAPT | |
| SCHEMBL17438150 | 0.70 | ALDH1A1 (0.41) | ALDH1A1MAPTKDM4ELMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925647-A | TREATMENT OF INSULIN NON-INSULIN DEPENDENT DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |