Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MASP2 | O00187 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479733 | 0.80 | ALDH1A1 (0.45) | KDM4ESMN1; SMN2RAB9ACYP2C9ALDH1A1 | |
| SCHEMBL8479485 | 0.80 | ALDH1A1 (0.49) | KDM4ENPC1RAB9AMAPK8CYP2C9 | |
| SCHEMBL8855171 | 0.78 | HTT (0.45) | KDM4EHTTSMN1; SMN2GRIK1NPC1 | |
| SCHEMBL8485493 | 0.75 | ALDH1A1 (0.44) | KDM4ESMN1; SMN2GRIK1NPC1RAB9A | |
| SCHEMBL8606406 | 0.73 | LMNA (0.48) | HTTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL9093965 | 0.70 | KEAP1 (0.41) | HTTSMN1; SMN2GRIK1NPC1RAB9A | |
| SCHEMBL4256425 | 0.70 | FABP4 (0.65) | KDM4EGRIK1MAPK8CYP2C9HPGD | |
| SCHEMBL17554068 | 0.68 | MEN1 (0.54) | KDM4ESMN1; SMN2RAB9AALDH1A1ALB | |
| SCHEMBL3930397 | 0.68 | TSPO (0.54) | KDM4ESMN1; SMN2ALDH1A1MASP2GAA | |
| SCHEMBL22532257 | 0.68 | ALDH1A1 (0.50) | KDM4EHTTSMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925647-A | TREATMENT OF INSULIN NON-INSULIN DEPENDENT DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| WO-1996010015-A1 | CRYPTOLEPINE ANALOGS WITH HYPOGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | disclosed |