Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | MELK | Q14680 | 2/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479733 | 0.87 | ALDH1A1 (0.45) | HPGDRAB9AKDM4EGAAALDH1A1 | |
| SCHEMBL8479485 | 0.86 | ALDH1A1 (0.49) | DAPK3PIM1CDK2FLT3GSK3B | |
| SCHEMBL9093965 | 0.85 | KEAP1 (0.41) | HTTHPGDNPC1RAB9AGAA | |
| SCHEMBL8485493 | 0.79 | ALDH1A1 (0.44) | HPGDNPC1RAB9AKDM4EGAA | |
| SCHEMBL8608850 | 0.78 | KDM4E (0.43) | HTTHPGDNPC1RAB9AMAPK8 | |
| SCHEMBL8606406 | 0.77 | LMNA (0.48) | HTTHPGDNPC1RAB9AGAA | |
| SCHEMBL9094525 | 0.74 | KDM4E (0.46) | HPGDNPC1RAB9AKDM4EGAA | |
| SCHEMBL9094581 | 0.74 | GRIK1 (0.48) | HPGDNPC1RAB9AKDM4EGAA | |
| SCHEMBL6823572 | 0.71 | RAB9A (0.58) | HTTHPGDNPC1RAB9AKDM4E | |
| SCHEMBL2700103 | 0.71 | HTT (0.71) | HTTHPGDNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| WO-1996010015-A1 | CRYPTOLEPINE ANALOGS WITH HYPOGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | disclosed |