Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8485493 | 0.91 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDGAAGLA | |
| SCHEMBL8479485 | 0.90 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDGAAGLA | |
| SCHEMBL8606406 | 0.88 | LMNA (0.48) | ALDH1A1HPGDGAARAB9ASMN1; SMN2 | |
| SCHEMBL8855171 | 0.87 | HTT (0.45) | ALDH1A1KDM4EHPGDGAAGLA | |
| SCHEMBL9094581 | 0.82 | GRIK1 (0.48) | ALDH1A1KDM4EHPGDGAAGLA | |
| SCHEMBL9094525 | 0.82 | KDM4E (0.46) | ALDH1A1KDM4EHPGDGAAGLA | |
| SCHEMBL9093965 | 0.82 | KEAP1 (0.41) | ALDH1A1HPGDGAARAB9ASMN1; SMN2 | |
| SCHEMBL8608850 | 0.80 | KDM4E (0.43) | ALDH1A1KDM4EHPGDGAAGLA | |
| SCHEMBL9094620 | 0.77 | PBRM1 (0.41) | ALDH1A1KDM4EHPGDGAAGLA | |
| SCHEMBL8483746 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925647-A | TREATMENT OF INSULIN NON-INSULIN DEPENDENT DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| WO-1996010015-A1 | CRYPTOLEPINE ANALOGS WITH HYPOGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | disclosed |