Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 5/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 2/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479733 | 0.91 | ALDH1A1 (0.45) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL8479485 | 0.87 | ALDH1A1 (0.49) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL8606406 | 0.86 | LMNA (0.48) | ALDH1A1GAAHPGDMAPTNPC1 | |
| SCHEMBL8855171 | 0.79 | HTT (0.45) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL8608850 | 0.75 | KDM4E (0.43) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL9093965 | 0.74 | KEAP1 (0.41) | ALDH1A1GAAHPGDDHODHMAPT | |
| SCHEMBL9094581 | 0.74 | GRIK1 (0.48) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL9094525 | 0.74 | KDM4E (0.46) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL5696478 | 0.71 | CDC25B (0.41) | ALDH1A1KDM4EGAAHPGDCDC25B | |
| SCHEMBL9094620 | 0.70 | PBRM1 (0.41) | ALDH1A1KDM4EGLAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925647-A | TREATMENT OF INSULIN NON-INSULIN DEPENDENT DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| WO-1996010015-A1 | CRYPTOLEPINE ANALOGS WITH HYPOGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | disclosed |