Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479733 | 0.77 | ALDH1A1 (0.45) | ALDH1A1TSHRKMT2AHPGDMEN1 | |
| SCHEMBL9094620 | 0.77 | PBRM1 (0.41) | ALDH1A1KMT2AHPGDMEN1LMNA | |
| SCHEMBL8478831 | 0.74 | TSHR (0.50) | ALDH1A1TSHRKMT2AHPGDMEN1 | |
| SCHEMBL9094581 | 0.73 | GRIK1 (0.48) | ALDH1A1TSHRKMT2AHPGDMEN1 | |
| SCHEMBL9094525 | 0.73 | KDM4E (0.46) | ALDH1A1TSHRHPGDAKR1C3KDM4E | |
| SCHEMBL6831109 | 0.73 | TSHR (0.57) | ALDH1A1TSHRKMT2AHPGDMEN1 | |
| SCHEMBL744075 | 0.71 | RAB9A (0.65) | TSHRKMT2AMEN1CYP3A4MAPT | |
| SCHEMBL30102270 | 0.70 | RAB9A (0.63) | ALDH1A1TSHRKMT2AHPGDMEN1 | |
| SCHEMBL8485493 | 0.70 | ALDH1A1 (0.44) | ALDH1A1HPGDMAPTKDM4EGLA | |
| SCHEMBL8855171 | 0.69 | HTT (0.45) | ALDH1A1KMT2AHPGDMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925647-A | TREATMENT OF INSULIN NON-INSULIN DEPENDENT DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| WO-1996010015-A1 | CRYPTOLEPINE ANALOGS WITH HYPOGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | disclosed |