Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.58 |
| ▸ | CFD | P00746 | 1/20 | 0.58 |
| ▸ | MASP2 | O00187 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9473974 | 0.86 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1ABCC1CFDMASP2 | |
| SCHEMBL4040223 | 0.83 | ALDH1A1 (0.82) | ALDH1A1L3MBTL1ABCC1CFDKDM4E | |
| SCHEMBL8437112 | 0.81 | ALDH1A1 (0.79) | ALDH1A1L3MBTL1ABCC1CFDKDM4E | |
| SCHEMBL5696443 | 0.78 | ALDH1A1 (0.73) | ALDH1A1L3MBTL1CFDKDM4ELMNA | |
| SCHEMBL14855999 | 0.78 | ALDH1A1 (0.73) | ALDH1A1L3MBTL1CFDKDM4ELMNA | |
| SCHEMBL7427911 | 0.78 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1ABCC1CFDKDM4E | |
| SCHEMBL9475280 | 0.77 | POLB (0.54) | ALDH1A1KDM4ELMNASMN1; SMN2POLB | |
| SCHEMBL9251459 | 0.77 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL22524956 | 0.76 | ABCC1 (0.55) | ALDH1A1L3MBTL1ABCC1CFDMASP2 | |
| SCHEMBL8511541 | 0.76 | HDAC1 (0.49) | ALDH1A1KDM4ELMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925647-A | TREATMENT OF INSULIN NON-INSULIN DEPENDENT DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| WO-1996010015-A1 | CRYPTOLEPINE ANALOGS WITH HYPOGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | disclosed |